• GSK, AstraZeneca in Talks to Help U.K. Government on Virus Tests

    U.K. pharmaceutical giants GlaxoSmithKline Plc and AstraZeneca Plc are in talks to set up a lab to explore new ways of testing for the coronavirus to help overcome shortages of diagnostic materials, according to a person with knowledge of the plans.
    Suzi Ring and James Paton write in Bloomberg that the drugmakers will evaluate the use of different raw materials needed to carry out the tests and use their know-how and resources to help other companies or the U.K.’s National Health Service increase production, according to the person, who asked not to be identified because the details of the discussions aren’t yet public.
    U.K. Health Secretary Matt Hancock pledged Thursday to increase coronavirus testing to 100,000 a day by the end of April. 

     

  • Coronavirus: China Floods Europe With Defective Medical Equipment

    As the coronavirus rages across Europe, a growing number of countries are reporting that millions of pieces of medical equipment donated by, or purchased from, China to defeat the pandemic are defective and unusable. Soeren Kern writes for the Gatestone Institute that the revelations are fueling distrust of a public relations effort by Chinese President Xi Jinping and his Communist Party to portray China as the world’s new humanitarian superpower. Two examples: In Spain, the Ministry of Health revealed that 640,000 coronavirus tests that it had purchased from a Chinese supplier were defective. In addition, a further million coronavirus tests delivered to Spain on March 30 by another Chinese manufacturer were also defective. The Czech news site iRozhlas reported that 300,000 coronavirus test kits delivered by China had an error rate of 80 percent. The Czech Ministry of Interior had paid $2.1 million for the kits.

  • These Drugs Don’t Target the Coronavirus—They Target Us

    In another example of the blinding speed at which science is moving during the pandemic era, researchers at Aarhus University in Denmark will start a clinical trial of a drug named camostat mesylate tomorrow—barely 1 month after Cell paper showed the compound can prevent the novel coronavirus, SARS-CoV-2, from entering human cells.
    Kai Kupferschmidt writes in Science that one reason the Danish researchers can act so fast is that camostat mesylate is already licensed in Japan and South Korea to treat pancreatitis, a potentially fatal inflammation of the pancreas. Enough safety data were available to convince an ethical panel to greenlight the trial.
    The trial also illustrates a new approach to combatting the virus. Thousands of researchers around the world are investigating existing drugs as potential therapies for COVID-19, most of them looking at antivirals, such as remdesivir, developed to treat Ebola, or Kaletra, a combination drug against HIV. But Nevan Krogan, a molecular biologist at the University of California, San Francisco, sees another opportunity: “The virus can’t live by itself, right? It needs our genes and proteins in order to live and to replicate.” Camostat mesylate is one of several candidate drugs that block those interactions. They don’t target the virus, but us, the host.

  • How the Coronavirus Pandemic Is Killing Cash

    There is much talk about how COVID-19 will change the world. There is less about how it is simply accelerating trends that were already underway. Merryn Somerset Webb writes in MoneyWeek that one to keep a particular eye on is a theme we have been watching for some time – the death of cash.
    No one wants to touch cash today. It’s always been known to be pretty filthy stuff; now it isn’t just grubby, it is potentially lethal. No wonder, then, that the use of cash has halved in the last week and that “card only” signs are appearing everywhere. Some large chains stopped taking card payments altogether (even before lockdown) and the contactless upper limit has been moved from £30 to £45.

  • There Are Many COVID-19 Tests in the U.S. – How Are They Being Regulated?

    When it comes to COVID-19 testing in the United States, the situation is about as messy as it gets. The U.S. went from having no tests, or assays, available for COVID-19 diagnostics to having multiple different tests available in a span of just a few weeks. Today more than 230 test developers have alerted the Food and Drug Administration that they are requesting emergency authorization for their tests; 20 have been granted. And 110 laboratories around the country, including my own, are also using their own tests. Having this number of diagnostic tests available to detect a single virus in such a short time frame is unprecedented.

  • British American Tobacco Working on Plant-Based Coronavirus Vaccine

    British American Tobacco, the maker of brands including Lucky Strike, Dunhill, Rothmans and Benson & Hedges, has said it has a potential coronavirus vaccine in development using tobacco plants. Mark Sweney writes in the Guardian that BAT has turned the vast resources usually focused on creating products that pose health risks to millions of smokers worldwide to battling the global pandemic.
    BAT said its US biotech subsidiary, Kentucky BioProcessing (KBP), has moved to pre-clinical testing and that it will work on the vaccine on a not-for-profit basis.
    BAT said it had cloned a portion of the genetic sequence of the coronavirus and developed a potential antigen. The antigen was then inserted into tobacco plants for reproduction and, once the plants were harvested, the antigen was purified. It is now undergoing pre-clinical testing.

  • Doctor Says “Knock-on-Effects” of Pandemic Chaos Could Be Deadlier than Virus

    The disruption being wrought on Israeli healthcare by the coronavirus crisis could kill more people than the disease itself, a leading doctor has claimed.
    The Times of Israel reports that the warning by Anthony Luder, director of the Pediatric Department at Ziv Medical Center in Safed, came as an influential think tank raised alarm bells that the “collateral” effect of the coronavirus crisis could lead to more deaths than the virus, and after a minister said he was worried about people taking their own lives.
    “We may have more suicides than deaths from coronavirus,” Defense Minister Naftali Bennett said on Tuesday, suggesting that the economic consequences will push some Israelis to kill themselves if the lockdown is kept in place for too long.
    Luder fears that a potentially lethal domino effect of the crisis will be felt in the very health system that is treating coronavirus patients. “It’s entirely plausible that more people will die of the knock-on effects than of coronavirus itself,” he told The Times of Israel.

  • The Data Speak: Stronger Pandemic Response Yields Better Economic Recovery

    With much of the U.S. in shutdown mode to limit the spread of the COVID-19 disease, a debate has sprung up about when the country might “reopen” commerce, to limit economic fallout from the pandemic. But as a new study co-authored by an MIT economist shows, taking care of public health first is precisely what generates a stronger economic rebound later. His study of the 1918 flu pandemic shows U.S. cities which responded more aggressively in health terms also had better economic rebounds.

  • Bellerophon Starts INOpulse Treatment in Coronavirus Patients

    Bellerophon Therapeutics has treated the first Covid-19 patient with its INOpulse at the University of Miami School of Medicine in the US.
    This comes after the company received emergency expanded access from the U.S. Food and Drug Administration (FDA) for the inhaled nitric oxide system (iNO).
    Clinical Trials Arena reports that NO is a naturally produced molecule that plays a key role in the immune response against pathogens and infections.
    In-vitro studies found that NO blocks the replication of severe acute respiratory syndrome-related coronavirus (SARS-CoV) and improves the survival of infected cells.

  • COVID-19: One in Five over-80s Need Hospitalization and Death Rate 0.66 Percent

    This is one of the conclusions of an analysis of 3,665 cases in mainland China, published in The Lancet Infectious Diseases. Laura Gallagher writes for Imperial College London that it also estimates that the overall death rate, including unconfirmed cases, is 0.66%. The estimated proportion of deaths from both diagnosed cases and from milder, unconfirmed cases is strongly influenced by age. The estimates are slightly lower than others that have been made for the virus, but are still much higher than for previous pandemics such as 2009 pandemic influenza H1N1, which was estimated to be fatal in around 0.02% of cases. The new estimates are based on an analysis of 70,117 laboratory-confirmed and clinically-diagnosed cases in mainland China, combined with 689 positive cases among people evacuated from Wuhan on repatriation flights.

  • Japan's Fujifilm Starts Avigan Trial to Treat Coronavirus

    Japan’s Fujifilm has begun clinical trials to test the effectiveness of its anti-flu drug Avigan in treating patients with the new coronavirus, after reports of promising results in China.
    The Bangkok Times reports that trials in China have suggested Avigan (generic name: favipiravir) could play a role in shortening the recovery time for patients infected with coronavirus.
    The drug will be administered for a maximum of 14 days to coronavirus patients between 20 and 74 years old with mild pneumonia, the spokesman said.
    The study excludes pregnant women due to side effects shown in animal testing, he added.

  • Pluristem Begins Dosing with Covid-19 Therapy in Israel

    Pluristem Therapeutics has started dosing Covid-19 patients in Israel with PLX cells under a compassionate use programme approved by the country’s health ministry.
    Dosing was performed in three patients at two hospitals. Pluristem intends to recruit more coronavirus patients in the coming days.
    Clinical Trials reports that PLX cells are off-the-shelf allogeneic mesenchymal-like cells with immunomodulatory properties that could trigger the immune system’s natural regulatory T-cells and M2 macrophages.
    This mechanism is expected to block the overactivation of the immune system, which leads to complications.
    It is hoped that the approach will potentially decrease the incidence and\or severity of pneumonia and pneumonitis associated with Covid-19 infection.

  • COVID-19 Therapeutics Accelerator Awards $20 Million to Fund Clinical Trials

    The COVID-19 Therapeutics Accelerator, a global initiative launched in March by the Bill & Melinda Gates Foundation, Wellcome, and Mastercard, has announced three grants totaling $20 million in support of efforts to identify repurposed drugs and immunotherapies for COVID-19.

  • Coronavirus: Mercedes F1 to Make Breathing Aid

    University College London engineers worked with clinicians at UCLH and Mercedes Formula One to build the device, which delivers oxygen to the lungs without needing a ventilator. Continuous Positive Airway Pressure (CPAP) devices are already used in hospitals but are in short supply.
    Fergus Walsh writes for the BBC that China and Italy used the devices to help Covid-19 patients. Forty of the new devices have been delivered to ULCH and to three other London hospitals. If trials go well, up to 1,000 of the CPAP machines can be produced per day by Mercedes-AMG-HPP, beginning in a week’s time.
    The Medicines and Healthcare products Regulatory Agency (MHRA) has already given its approval for their use.
    Meanwhile a consortium of U.K. industrial, technology and engineering businesses in the U.K. has come together to produce medical ventilators for the NHS. The “VentilatorChallengeUK” consortium includes Airbus, BAE Systems, Ford, Rolls-Royce and Siemens.

  • A New Way of Developing Vaccines for COVID-19 Could Help the World to Prepare for Future Outbreaks

    Vaccines are one of our greatest tools to protect against infectious diseases and the world waits with bated breath for a vaccine against coronavirus (COVID-19). The wait might be much shorter if we can hone new methods of vaccine development. Charlie Weller writes for Wellcome Trust that although it has been just nine weeks since scientists around the world received the genetic code for COVID-19, a phase 1 clinical trial for a vaccine (mRNA-1273)(opens in a new tab) has already begun. This timescale from genomic sequence to clinical trial is unprecedented in vaccine development.
    This vaccine, unlike traditional vaccines, has been developed using ribonucleic acid (RNA) technology. If successful, the cutting-edge method could revolutionize vaccine development for future disease outbreaks.