• Coronavirus: China Floods Europe With Defective Medical Equipment

    As the coronavirus rages across Europe, a growing number of countries are reporting that millions of pieces of medical equipment donated by, or purchased from, China to defeat the pandemic are defective and unusable. Soeren Kern writes for the Gatestone Institute that the revelations are fueling distrust of a public relations effort by Chinese President Xi Jinping and his Communist Party to portray China as the world’s new humanitarian superpower. Two examples: In Spain, the Ministry of Health revealed that 640,000 coronavirus tests that it had purchased from a Chinese supplier were defective. In addition, a further million coronavirus tests delivered to Spain on March 30 by another Chinese manufacturer were also defective. The Czech news site iRozhlas reported that 300,000 coronavirus test kits delivered by China had an error rate of 80 percent. The Czech Ministry of Interior had paid $2.1 million for the kits.

  • These Drugs Don’t Target the Coronavirus—They Target Us

    In another example of the blinding speed at which science is moving during the pandemic era, researchers at Aarhus University in Denmark will start a clinical trial of a drug named camostat mesylate tomorrow—barely 1 month after a Cell paper showed the compound can prevent the novel coronavirus, SARS-CoV-2, from entering human cells.
    Kai Kupferschmidt writes in Science that one reason the Danish researchers can act so fast is that camostat mesylate is already licensed in Japan and South Korea to treat pancreatitis, a potentially fatal inflammation of the pancreas. Enough safety data were available to convince an ethical panel to greenlight the trial.
    The trial also illustrates a new approach to combatting the virus. Thousands of researchers around the world are investigating existing drugs as potential therapies for COVID-19, most of them looking at antivirals, such as remdesivir, developed to treat Ebola, or Kaletra, a combination drug against HIV. But Nevan Krogan, a molecular biologist at the University of California, San Francisco, sees another opportunity: “The virus can’t live by itself, right? It needs our genes and proteins in order to live and to replicate.” Camostat mesylate is one of several candidate drugs that block those interactions. They don’t target the virus, but us, the host.

  • How the Coronavirus Pandemic Is Killing Cash

    There is much talk about how COVID-19 will change the world. There is less about how it is simply accelerating trends that were already underway. Merryn Somerset Webb writes in MoneyWeek that one to keep a particular eye on is a theme we have been watching for some time – the death of cash.
    No one wants to touch cash today. It’s always been known to be pretty filthy stuff; now it isn’t just grubby, it is potentially lethal. No wonder, then, that the use of cash has halved in the last week and that “card only” signs are appearing everywhere. Some large chains stopped taking card payments altogether (even before lockdown) and the contactless upper limit has been moved from £30 to £45.

  • Global COVID-19 Total Races Past 1 Million Mark

    After just four months, the global COVID-19 total topped the 1 million mark yesterday, with more countries on several continents reporting exponential growth, even in some African nations. Meanwhile, the world’s number of deaths from the virus passed 50,000, with more than half of them from Europe’s hot spots. The Johns Hopkins online tracker shows 1,002,159 cases and 51,485 deaths.

  • There Are Many COVID-19 Tests in the U.S. – How Are They Being Regulated?

    When it comes to COVID-19 testing in the United States, the situation is about as messy as it gets. The U.S. went from having no tests, or assays, available for COVID-19 diagnostics to having multiple different tests available in a span of just a few weeks. Today more than 230 test developers have alerted the Food and Drug Administration that they are requesting emergency authorization for their tests; 20 have been granted. And 110 laboratories around the country, including my own, are also using their own tests. Having this number of diagnostic tests available to detect a single virus in such a short time frame is unprecedented.

  • DOJ: Deliberately Spreading COVID-19 to Be Prosecuted as Domestic Terrorism

    As panic and fear spread with the COVID-19 pandemic, stupid, or malicious, acts may soon be considered criminal offenses and subject to terrorism laws. DOJ has circulated a memo to law enforcement and federal prosecutors saying that deliberate acts to spread the coronavirus could be prosecuted under federal terrorism laws given that the virus is a biological agent.

  • Russia Using COVID-19 Disinformation, Conspiracy Theories to “Subvert the West”: Repot

    Russian President Vladimir Putin and his administration are using the coronavirus crisis to spread conspiracy theories in a bid to “subvert the West” and create a new world order, a new report has charges. The report says that Russia was propagating disinformation and conspiracy theories via social media accounts, fake news outlets, state-controlled media, pseudo-scientists and Russians living in the West.

  • Social Media Can Help Track the Spread of Disease

    Disease surveillance means monitoring the spread of disease through populations in order to establish patterns and minimize harm caused by outbreaks. A recent study explored how to effectively and ethically include social media and broader Internet tracking as part of public health surveillance efforts.

  • Tracking the Spread of Disease on Social Media

    For many years, researchers have turned to the public logs of search engine terms to help them track the spread of disease. They can analyze the keywords and phrases that people use and when they become interested in a disease or have symptoms.

  • Tests of Potential Coronavirus Vaccine Spur Growth of Virus-Fighting Antibodies

    A potential vaccine for COVID-19 has been developed and tested successfully in mice, researchers reported Thursday. “We’d like to get this into patients as soon as possible,” said Andrea Gambotto, associate professor of surgery at the University of Pittsburgh School of Medicine and co-author of a paper announcing the vaccine in the journal EBioMedicine.
    As far as reaching clinical trials, “we would like to think a month, give or take. Maybe two months. We just started the process,” said co-author Louis Falo, a professor and chairman of the Department of Dermatology at the University of Pittsburgh.
    Mark Johnson writes in USA Today that vaccines often take years to receive approval from the U.S. Food and Drug Administration. Yet on March 16, the first four healthy volunteers in Seattle received a different potential COVID-19 vaccine, made by a company called Moderna and administered in a small clinical trial at Kaiser Permanente Washington Health Research Institute.
    Though the vaccine being tested in Seattle uses a new, faster but untested technology, the one developed in Pittsburgh employs the same technique used in flu shots. The Pittsburgh vaccine uses lab-made viral protein to build a person’s immunity to the virus.

  • Don’t Believe the COVID-19 Models: That’s Not What They’re for.

    Since the onset of the coronavirus crisis, governments, analysts, and health organizations have released different statistical models addressing the disease – and its numerical manifestations: the number of people likely to be infected; hospitalized; treated in the ICUs; or die. Different models offer different numbers and different trajectories. Which one of them is right? Zeynep Tufecki writes that “The answer is both difficult and simple. Here’s the difficult part: There is no right answer. But here’s the simple part: Right answers are not what epidemiological models are for.” The most important function of epidemiological models is as a simulation, a way to see our potential futures ahead of time, and how that interacts with the choices we make today. Thus, epidemiological models do not give us certainty – they give us something much more important: “agency to identify and calibrate our actions with the goal of shaping our future.”

  • “Dunkirk” Effort to Boost Coronavirus Testing Begins

    A “Dunkirk” effort from smaller labs to meet the massive demand for coronavirus tests is finally under way after ministers lost patience with efforts by public health officials.
    Francis Elliott and Rhys Blakely write in The Times that the head of the respected Francis Crick Institute urged the government to move away from the cumbersome “big boats” of testing — Public Health England (PHE) and the NHS — towards smaller organizations like his to increase the level of testing of frontline staff, which stood at just 2,000 yesterday.
    Sir Paul Nurse, director of the Crick, said: “Institutes like ours are coming together with a Dunkirk spirit — small boats that collectively can have a huge impact on the national endeavor.”
    He added: “The government has put some big boats, destroyers in place. That’s a bit more cumbersome to get working and we wish them all the luck to do that, but we little boats can contribute as well.”
    The Crick and 300 of its staff, Europe’s biggest biomedical research facility, volunteered help two weeks ago but have been kept waiting ever since.
    It was also reported that employees at the Animal and Plant Health Agency (APHA) believe that PHE failed to utilize its capacity to deliver 40,000 tests a week two months after it was first identified.

  • British American Tobacco Working on Plant-Based Coronavirus Vaccine

    British American Tobacco, the maker of brands including Lucky Strike, Dunhill, Rothmans and Benson & Hedges, has said it has a potential coronavirus vaccine in development using tobacco plants. Mark Sweney writes in the Guardian that BAT has turned the vast resources usually focused on creating products that pose health risks to millions of smokers worldwide to battling the global pandemic.
    BAT said its US biotech subsidiary, Kentucky BioProcessing (KBP), has moved to pre-clinical testing and that it will work on the vaccine on a not-for-profit basis.
    BAT said it had cloned a portion of the genetic sequence of the coronavirus and developed a potential antigen. The antigen was then inserted into tobacco plants for reproduction and, once the plants were harvested, the antigen was purified. It is now undergoing pre-clinical testing.

  • InflaRx Starts Dosing COVID-19 Patients in Europe

    German biopharmaceutical firm InflaRx has enrolled and dosed the first patient in a clinical study of IFX-1 in Covid-19 patients with severe pneumonia in the Netherlands.
    Clinical Trials Arena reports thatIFX-1 is a monoclonal anti-human complement factor C5a antibody designed to inhibit the biological activity of C5a. The drug is not believed to impact the formation of the membrane attack complex (C5b-9).
    According to preclinical data, IFX-1 showed ability to control the inflammatory response-related tissue and organ damage via a selective blockade of C5a in the adaptive, randomized, controlled trial.
    The drug was found to be well tolerated in around 300 clinical trial participants, according to the company.
    IFX-1 is currently in development to treat inflammatory conditions such as hidradenitis suppurativa, ANCA-associated vasculitis, and pyoderma gangraenosum.

  • A Corona Test that Can Be Done Over the Phone

    Voice analysis can achieve amazing results, such as accurately guessing the shape of a speaker’s face, accurately guessing whether the speaker has been drinking tea or coffee, or diagnosing a variety of different diseases. While new, this field has already drawn the interest of academics, Israeli startups, and companies around the world.

    Shem Ur, a professional inventor, writes in the Times of Israel that he has decided to develop an over-the-phone coronavirus phone test. He writes:

    Right now, we are working to create software that can detect the coronavirus infection using only a person’s voice. For this, we need voice data from as many people as possible. Please help us by completing our voice questionnaire at Corona Voice Detect.

    If you know anybody who has tested positive, please ask them to complete the questionnaire as well. Their voice data is especially necessary for creating a program that can identify infections. If you think your friends, relatives, or anyone else might want to do this, please share it with them. The ability to identify infections is key to managing the situation and every piece of data will help us do this more effectively.