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Biological emergences: Incremental progress not enough
While acknowledging some positive efforts over the past year by the White House and Congress, the bipartisan Blue Ribbon Study Panel on Biodefense says the incremental progress is not enough to defend against biological emergencies, let alone catastrophic events. The report, Biodefense Indicators – One Year Later, Events Outpacing Federal Efforts to Defend the Nation, states that while the biological threat is real and continues to grow, our nation remains woefully under-prepared for dangerous biological incidents.
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Developing the National Livestock Readiness Program
The National Agricultural Biosecurity Center has received $331,118 from the Department of Homeland Security through its Basic Ordering Agreement with K-State to develop the National Livestock Readiness Program. The project, with its initial deliverables completed by September 2017, will provide a clearinghouse for planning, training, and knowledge products to help state and local entities prepare for transboundary livestock disease outbreaks.
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Real-time online epidemic tracking tool relies on open data, collective intelligence
Until now, disease data and geographic information about the movement of an infection or disease as it evolves and spreads has been locked up in databases that are often out of people’s reach. Researchers have been left to rely on published information in research papers, which may be many months out of date, containing static visuals which show only a small part of the whole disease or infection threat. Now, researchers have developed Microreact, a free, real-time epidemic visualization and tracking platform that has been used to monitor outbreaks of Ebola, Zika, and antibiotic-resistant microbes.
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Emergent BioSolutions to supply up to $1 billion of anthrax vaccine to the Strategic National Stockpile
Emergent BioSolutions signed follow-on contract with CDC valued at up to $911 million to supply to the Strategic National Stockpile (SNS) approximately 29.4 million doses of BioThrax through September 2021. BARDA issued notice of intent to separately procure approximately $100 million of BioThrax for the SNS over twenty-four months from contract award, which is expected in 1H 2017. These actions, together with the recently awarded BARDA contract for NuThrax, reflect the U.S. government’s intention to transition the stockpile of anthrax vaccines from BioThrax to NuThrax.
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$19 million to develop drugs to treat victims of chemical weapons attacks
First used by the German military against Allied troops in the First World War and in subsequent wars including the Iran-Iraq conflict during the 1980s, chemical weapons were more recently used by the Assad regime in Syria and by ISIS in Iraq and Syria. The National Institutes of Health (NIH) has awarded Rutgers University a five-year grant for more than $19 million for research that would lead to the development of drugs to treat toxicity from chemical agents used in a terrorist attack.
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Predicting disease outbreak in a hyper-connected world
At the first hints of a disease outbreak, epidemiologists, health care providers, policy makers, and scientists turn to sophisticated predictive models to determine how an illness is spreading and what should be done to minimize contagion. New research is upending the traditional modeling process, yielding predictions that are both simpler to calculate and more attuned to a hyper-connected world.
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Common grass to help boost food security
Common Panic grasses could hold the secret to increasing the yields of cereal crops and help feed the world with increasing temperature extremes and a population of nearly ten billion people by 2050. The grasses have the potential to improve crop yields for staple foods such as wheat and rice by transplanting enzymes from Panic grasses.
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Symptomless Ebola – questions need to be answered before the next outbreak
Scientists know that Ebola can cause anything from severe hemorrhagic fever to no symptoms at all (asymptomatic infections). What wasn’t known, until now, is the number of people who experienced asymptomatic infections during the 2013-2016 outbreak of Ebola in West Africa. While the new report of asymptomatic cases of Ebola virus infection is not unique, it does raise important questions that need to be answered. Over the last couple of years, governments and global public health agencies have increased resources to tackle these questions. Hopefully, we will be better equipped and prepared for the next outbreak.
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Supercomputer simulations help develop new approach to tackle antibiotic resistance
Supercomputer simulations at the Department of Energy’s Oak Ridge National Laboratory have played a key role in discovering a new class of drug candidates that hold promise to combat antibiotic resistance. Researchers combined lab experiments with supercomputer modeling to identify molecules that boost antibiotics’ effect on disease-causing bacteria.
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Changes required to fortify U.S. blood system against financial, biological threats
The U.S. blood system collects, tests, processes, and distributes the blood that is ultimately used in clinical practice. In 2013, more than 14 million units of blood were collected in the United States from about 15.2 million individuals, with 13.2 million units transfused. Medical advances have reduced the demand for blood in the United States, creating financial pressure on the nation’s blood collection centers and threatening their future survival.
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Improving biosafety, biosecurity in West Africa
The Defense Threat Reduction Agency and United States Strategic Command Center for Combating Weapons of Mass Destruction (DTRA/SCC-WMD) have selected CH2M to lead efforts in West Africa to broaden its Cooperative Biological Engagement Program (CBEP) on the African continent and reduce the threat of infectious diseases. The CBEP, developed by the Department of Defense to address global health security issues, was used in 2014 to support international efforts to combat the Ebola virus outbreak and other threats to global health security.
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Israel Red Cross affiliate building underground blood bank to ensure supply during crises
Magen David Adom, the Israeli affiliate of the Red Cross, is building an underground blood bank in order to secure the country’s blood supply in case of attacks or natural disasters. “With all blood transfusions stored in an underground space, the facility will ensure that they remain unharmed even when the building is under a massive barrage of missiles,” Magen David Adom director said. The terror organization Hezbollah has an estimated arsenal of over 130,000 rockets capable of firing at Israel — more than the combined amount of the twenty-seven non-U.S. NATO member states.
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People with Ebola may not always show symptoms
A research team determined that 25 percent of individuals in a Sierra Leone village were infected with the Ebola virus but had no symptoms, suggesting broader transmission of the virus than originally thought. These individuals had antibodies to the virus, suggesting they had been infected at one time — yet said they had had no symptoms during the time of active transmission in the village. Theresearch confirms previous suspicions that the Ebola virus does not uniformly cause severe disease, and that people may be infected without showing signs of illness.
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Stronger gun laws linked to decreased firearm homicides
Stronger firearm laws are associated with reductions in firearm homicide rates, concludes a study which reviewed all available articles published in peer-reviewed journals from January 1970 to August 2016 that focused specifically on the connection between firearm homicide and firearm laws. Specifically, the laws that seemed to have the most effect were those that strengthened background checks and those that required a permit to purchase a firearm. Laws that banned assault weapons, improved child safety, or aimed to limit firearm trafficking had no clear effect on firearm homicide rates. Laws that aimed to restrict guns in public places had mixed results.
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Ultra-long acting pill releases daily doses of medicine for a month
Imagine swallowing a pill today that continues releasing the daily dose of a medicine you need for the next week, month, or even longer. Investigators have developed a long-acting drug delivery capsule that may help to do just that in the future. To test the capsule’s real-world applications, the team used both mathematical modeling and animal models to investigate the effects of delivering a sustained therapeutic dose of a drug called ivermectin, which is used to treat parasitic infections such as river blindness. Ivermectin has an added bonus of helping keep malaria-carrying mosquito populations at bay.
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More headlines
The long view
What We’ve Learned from Survivors of the Atomic Bombs
Q&A with Dr. Preetha Rajaraman, New Vice Chair for the Radiation Effects Research Foundation in Hiroshima and Nagasaki, Japan.
Combatting the Measles Threat Means Examining the Reasons for Declining Vaccination Rates
Measles was supposedly eradicated in Canada more than a quarter century ago. But today, measles is surging. The cause of this resurgence is declining vaccination rates.
Social Networks Are Not Effective at Mobilizing Vaccination Uptake
The persuasive power of social networks is immense, but not limitless. Vaccine preferences, based on the COVID experience in the United States, proved quite insensitive to persuasion, even through friendship networks.
Vaccine Integrity Project Says New FDA Rules on COVID-19 Vaccines Show Lack of Consensus, Clarity
Sidestepping both the FDA’s own Vaccines and Related Biological Products Advisory Committee and the CDC’s Advisory Committee on Immunization Practices (ACIP), two Trump-appointed FDA leaders penned an opinion piece in the New England Journal of Medicine to announce new, more restrictive, COVID-19 vaccine recommendations. Critics say that not seeking broad input into the new policy, which would help FDA to understand its implications, feasibility, and the potential for unintended consequences, amounts to policy by proclamation.
Are We Ready for a ‘DeepSeek for Bioweapons’?
Anthropic’s Claude 4 is a warning sign: AI that can help build bioweapons is coming, and could be widely available soon. Steven Adler writes that we need to be prepared for the consequences: “like a freely downloadable ‘DeepSeek for bioweapons,’ available across the internet, loadable to the computer of any amateur scientist who wishes to cause mass harm. With Anthropic’s Claude Opus 4 having finally triggered this level of safety risk, the clock is now ticking.”
“Tulsi Gabbard as US Intelligence Chief Would Undermine Efforts Against the Spread of Chemical and Biological Weapons”: Expert
The Senate, along party lines, last week confirmed Tulsi Gabbard as Director of National intelligence. One expert on biological and chemical weapons says that Gabbard’s “longstanding history of parroting Russian propaganda talking points, unfounded claims about Syria’s use of chemical weapons, and conspiracy theories all in efforts to undermine the quality of the community she now leads” make her confirmation a “national security malpractice.”