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Enzymes versus nerve agents: Designing antidotes for chemical weapons
Nerve agents, a class of synthetic phosphorous-containing compounds, are among the most toxic substances known. Brief exposure to the most potent variants can lead to death within minutes. Once nerve agents enter the body, they irreversibly inhibit a vitally important enzyme called acetylcholinesterase. Its normal job within the nervous system is to help brain and muscle communicate. When a nerve agent shuts down this enzyme, classes of neurons throughout the central and peripheral nervous systems quickly get overstimulated, leading to profuse sweating, convulsions and an excruciating death by asphyxiation. There is a path to mitigate the danger of chemical weapons. This route lies within the domains of science – the very same science that produced chemical weapons in the first place. Researchers in the United States and around the world are developing the tools needed to quickly and safely destroy nerve agents – both in storage facilities and in the human body. There are promising advances, but no enzyme yet exists which is efficient enough for lifesaving use in people. It is worth keeping in mind the awesome and often complex power of science, however: We may be only a few years away from developing the kind of therapeutics that would make chemical weapons a worry of the past.
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The Assad regime’s chemical-weapons kill chain
“There’s a long list of Syrian officials with blood on their hands — but the culpability goes all the way to the top,” Gregory Koblentz writes in one of the more important analyses of the Assad regime’s strategic use of chemical weapons (“Syria’s Chemical Weapons Kill Chain,” Foreign Policy, 7 April 2017). Koblentz, the author of Living Weapons: Biological Warfare and International Security, explains that the Syrian chain of command for chemical weapons is composed of four tiers: the senior leadership, which authorizes the use of these weapons and provides strategic guidance; the chemists, who produce, transport, and prepare the chemical weapons for use; the coordinators, who provide intelligence on targets and integrate chemical weapons with conventional military operations; and the triggermen, who deliver the weapons to their targets. “Together, these individuals and organizations form a chemical-weapons kill chain,” Koblentz writes.
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Automated, real-time automobile cow-avoidance device
India has the second largest road network in the world, and a large number of traffic accidents: 1 in 20,000 people die there in a road traffic accident, and 12 in 70,000 are seriously injured in such accidents. India also has a large number of cows roaming streets and roads, and a large number of incidents in which cars run into loitering cows. India researchers have developed a real-time automatic obstacle detection and alert system which determines whether an object near the vehicle is an on-road cow and whether or not its movements represent a risk to the vehicle. If the cow poses a risk to the vehicle, an audio or visual indicator then alerts the driver to apply the brakes.
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U.S. strikes Syrian airbase from which Assad forces launched sarin gas attack
The United States has launched fifty-nine Tomahawk cruise missiles on a Syrian airfield from which Syrian military planes three days ago flew to carry out a sarin gas attack against Sunni civilians in the rebel-held Idlib province. More than eighty people, including thirteen children, were killed in the attack – and in a subsequent attack by the Syrian Air Force which destroyed the hospital to which many of the victims of the gas attack were taken. The cruise missiles were launched from the guided-missile destroyers USS Ross and Porter in the eastern Mediterranean. The United States has had military advisers and specialist on the ground in Syria for a while – it now has about 1,000 soldiers in Syria — advising the anti-regime rebels – especially the Syrian Kurds – but last night cruise missile attack marks the first time the United States has been involved as a combatant in the Syrian conflict.
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Will the U.S. missile strike be the turning point in Syria’s shifting war?
The United States has struck the Syrian airbase used to launch a suspected sarin gas attack against Khan Sheikhun that killed more than eighty civilians. The rebel commander whose district was hit by the suspected chemical weapon attack has said he hopes the strike will be a “turning point” in the war — but the long-running conflict has had many such apparently pivotal moments. A shift of U.S. foreign policy on Syria could have been the game-changer. But the U.S. airstrike is more likely to reinforce the balance of power between the combating factions rather than lead to a turning point.
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DHS S&T opens new explosives detection lab
DHS S&T officially opened a new Test & Evaluation Laboratory building at the Transportation Security Laboratory (TSL) on Wednesday. Located at the William J. Hughes FAA Technical Center in Egg Harbor Township, New Jersey, the new building expands TSL’s reinforced laboratory space for conducting tests of explosives detection systems. TSL is the only laboratory authorized to provide certification and qualification testing of explosives detection systems for the TSA.
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Super sponge effectively removes toxins from lakes
Mercury is very toxic and can cause long-term health damage, but removing it from water is challenging. To address this growing problem. Researchers have created a sponge that can absorb mercury from a polluted water source within seconds. The sponge converts the contamination into a non-toxic complex so it can be disposed of in a landfill after use. The sponge also kills bacterial and fungal microbes.
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Reusable sponge soaks up oil, revolutionizes oil spill, diesel cleanup
When the Deepwater Horizon drilling pipe blew out seven years ago, beginning the worst oil spill in U.S. history, those in charge of the recovery discovered a new wrinkle: the millions of gallons of oil bubbling from the sea floor weren’t all collecting on the surface where it could be skimmed or burned. Some of it was forming a plume and drifting through the ocean under the surface. Now, scientists have invented a new foam, called Oleo Sponge, that addresses this problem. The material not only easily absorbs oil from water, but is also reusable and can pull dispersed oil from the entire water column—not just the surface.
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At least 58 killed in Syrian army’s chemical attack in rebel-held Idlib province
At least fifty-eight people were killed in a chemical attack the Syrian military launched by against a rebel-held Syrian town in Idlib province Tuesday morning. Medics rushed scores of injured civilians to a hospital – but the Syrian air force then bombed the hospital, reducing it to rubble. This is the third reported chemical attack in Syria in just over a week. The previous two were reported in Hama province, in an area not far from Khan Sheikhoun, the site of Tuesday’s attack.
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“Lab-on-a-glove” brings nerve-agent detection to a wearer's fingertips
Organophosphate nerve agents, including sarin and VX, are highly toxic and can prevent the nervous system from working properly. Organophosphate pesticides are far less potent but work in a similar way and can cause illness in people who are exposed to them, according to the U.S. Centers for Disease Control and Prevention. Detecting either type of these sets of compounds accurately and quickly could help improve both defense and food security measures.
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Nextgen robots for nuclear clean-up
The cost of cleaning up the U.K.’s existing nuclear facilities has been estimated to be between £95 billion, and £219 billion over the next 120 years or so. The harsh conditions within these facilities means that human access is highly restricted and much of the work will need to be completed by robots. Present robotics technology is simply not capable of completing many of the tasks that will be required. A research a consortium to build the next generation of robots that are more durable and perceptive for use in nuclear sites.
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Declassifying rescued nuclear test films
The United States conducted 210 atmospheric nuclear tests between 1945 and 1962, with multiple cameras capturing each event at around 2,400 frames per second. But in the decades since, around 10,000 of these films sat idle, scattered across the country in high-security vaults. Not only were they gathering dust, the film material itself was slowly decomposing, bringing the data they contained to the brink of being lost forever. For the past five years, physicists, film experts, archivists, and software developers have been on a mission to hunt down, scan, reanalyze, and declassify these decomposing films. The goals are to preserve the films’ content before it is lost forever, and provide better data to the post-testing-era scientists.
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“Fishing out” radioactive elements from nuclear waste
Scientists have revealed how arsenic molecules might be used to “fish out” the most toxic elements from radioactive nuclear waste — a breakthrough that could make the decommissioning industry even safer and more effective. “Nuclear power could potentially produce far less carbon dioxide than fossil fuels, but the long-lived waste it produces is radioactive and needs to be handled appropriately,” one scientists said.
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Detecting weapons-grade uranium from afar
It is hard enough to identify nuclear materials when you can directly scan a suspicious suitcase or shipping container. But if you cannot get close? A technique for detecting enriched uranium with lasers could help regulators sniff out illicit nuclear activities from as far as a couple of miles away.
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Radiation threat detection system successfully tested in Washington, D.C.
DARPA’s SIGMA program — whose goal is to prevent attacks involving radiological “dirty bombs” and other nuclear threats — concluded its biggest and longest test deployment of vehicle-mounted radiation detectors in Washington, D.C., in February. For approximately seven months starting in July 2016, the fleet of D.C. Fire and Emergency Medical Services ambulances was outfitted with DARPA-developed nuclear and radiological detectors, providing the first city-scale, dynamic, real-time map of background radiation levels throughout the Capital as well as identifying any unusual spikes that could indicate a threat.
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More headlines
The long view
What We’ve Learned from Survivors of the Atomic Bombs
Q&A with Dr. Preetha Rajaraman, New Vice Chair for the Radiation Effects Research Foundation in Hiroshima and Nagasaki, Japan.