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PerspectiveThe Presidential Candidates Are Ignoring One of the World’s Biggest Looming Threats
Whoever sits in the Oval Office come January 2021, he or she will almost inevitably have to address pandemic disease as a foreign-policy issue. The well-being of Americans in today’s globalized world is inextricably linked to that of people around the globe, while the effects of pandemics are born disproportionately by the least powerful. The next U.S. president needs a proactive strategic initiative, based in global solidarity, to address today’s pandemics, tomorrow’s outbreaks, and the health impacts of climate change.
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Perspective: War crimes12 Hours. 4 Syrian Hospitals Bombed. One Culprit: Russia.
The Bashar al-Assad regime in Syria represents the Alawite minority (in 2011, about 75 percent of the Syrian population was Sunni , and about 12 percent were Alawites). Since the civil war in Syria began in 2011, the Assad regime, in the largest ethnic cleansing campaign since the end of the Second World War, has methodically, and successfully, pursued the goal of drastically reducing the number of Sunni Muslims in Syria. So far, the Assad regime has killed more than 500,000 Syrian Sunnis; has driven more than 5.6 million Sunnis out of Syria; and internally displaced more than 6.6 million Sunnis. One of the keys to Assad’s ethnic cleansing campaign has been the systematic destruction of hospitals and medical facilities in Sunni-majority areas and the killing of medical personnel. This strategy increases the number of dead and untreated wounded among the Sunnis, and along with the methodical destruction of water and sewage treatment facilities, makes life even more unbearable in Sunni areas of Syria. Since September 2015, the Russian air force has been doing most of the destruction of medical facilities and other civilian infrastructure in Sunni-majority areas.
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PerspectivePresident Trump Bars Uninsured Immigrants from the U.S.
On Oct. 4, President Trump issued a proclamation that bars otherwise qualified visa applicants from entry into the United States unless they are likely to obtain “approved health insurance” within 30 days of entry. The insurance test relies on 8 U.S.C.§ 1182(f), authorizing the president to bar entry of foreign nationals “detrimental to the interests of the United States”—the same provision that Trump used for his travel ban, which the Supreme Court upheld in Trump v. Hawaii. While the Supreme Court in Hawaii relied on the national security and foreign affairs rationale for the travel ban, the insurance test targets the very different issue of immigrants’ financial resources.
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Preventable diseasesClose-Knit, Vaccine-Reluctant Communities Stoked Measles: CDC
From 1 January to 1 October of this year, the United States tracked 22 measles outbreaks and 1,249 cases, according to a new overview published today by the Centers for Disease Control and Prevention (CDC) in Morbidity and Mortality Weekly Report (MMWR). “Eight outbreaks —defined as three or more related cases — that occurred in underimmunized, close-knit communities accounted for 85 percent of all cases,” the CDC said. And 75 percent of all cases in 2019 were part of outbreaks among Orthodox Jewish populations in New York State and City.
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GunsFunding for Research on Gun Injuries to U.S. Children Gets 30 Times Less Funding Per Death Than other causes
Firearm injuries kill 2,500 American children each year and send another 12,000 to emergency departments. But a new study finds that the nation spends far less on studying what led to those injuries, and what might prevent and treat them, than it spends on other, less-common causes of death in children between the ages of 1 and 18 years.
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Perspective: SuperbugsEngineered Viruses Could Fight Drug Resistance
In the battle against antibiotic resistance, many scientists have been trying to deploy naturally occurring viruses called bacteriophages that can infect and kill bacteria. Bacteriophages kill bacteria through different mechanisms than antibiotics, and they can target specific strains, making them an appealing option for potentially overcoming multidrug resistance. However, quickly finding and optimizing well-defined bacteriophages to use against a bacterial target is challenging. MIT biological engineers showed that they could rapidly program bacteriophages to kill different strains of E. coli by making mutations in a viral protein that binds to host cells. These engineered bacteriophages are also less likely to provoke resistance in bacteria, the researchers found.
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Perspective: Lyme vaccinationWhy There’s Still No Lyme Vaccine for Humans
There is no vaccine for Lyme disease, and Valneva, a French biotech company focused on developing vaccines for infectious diseases, hopes to change that. Valneva’s Lyme vaccine isn’t the first designed for people. Twenty years ago, Reeder could have been immunized. From 1999 to 2002, SmithKline Beecham—now GlaxoSmithKline—sold a Lyme vaccine called LYMErix. But the company pulled LYMErix off the market after a public backlash and a spate of lawsuits. If the new vaccine does make it to market, will it fare any better than LYMErix?
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Food securityClimate Change Could Cause Drought in Wheat-Growing Areas
In a new study, researchers found that unless steps are taken to mitigate climate change, up to 60 percent of current wheat-growing areas worldwide could see simultaneous, severe and prolonged droughts by the end of the century. Wheat is the world’s largest rain-fed crop in terms of harvested area and supplies about 20 percent of all calories consumed by humans.
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Nuclear warIndia-Pakistan Nuclear War Could Kill Millions, Lead to Global Starvation
A nuclear war between India and Pakistan could, over the span of less than a week, kill 50-125 million people—more than the death toll during all six years of World War II, according to new research. The researchers calculated that an India-Pakistan war could inject as much as 80 billion pounds of thick, black smoke into Earth’s atmosphere. That smoke would block sunlight from reaching the ground, driving temperatures around the world down by an average of between 3.5-9 degrees Fahrenheit for several years. Worldwide food shortages would likely come soon after. Today, India and Pakistan each have about 150 nuclear warheads at their disposal, and that number is expected to climb to more than 200 by 2025.
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Food safetyFDA: New Food Safety Dashboard to Track FSMA Progress
In an effort to enhance compliance with the Food Safety and Modernization Act (FSMA), the Food and Drug Administration (FDA) launched a new dashboard that will track and monitor how companies are implementing parts of the law, and how those changes are affecting the food safety system.
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Nuclear accidentsContaining a Nuclear Accident with Ground-up Minerals
Researchers at Sandia National Laboratories are developing a promising new way to prevent the spread of radioactive contamination and contain the hot molten mass that develops within a nuclear reactor during a catastrophic accident. A team of scientists discovered and patented a process for injecting sand-like minerals into the core of a nuclear reactor during an accident to contain and slow down the progression of a meltdown.
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Perspective: PandemicsGlobal Pandemic Threat: “Human Error” Leak of Lab Virus Now a “Substantial Probability”
Lynn Klotz, Senior Science Fellow at the Centre for Arms Control and Non-Proliferation said: “There is a substantial probability that a pandemic with over one hundred million fatalities could be seeded from an undetected lab-acquired infection.” Laboratories run by Ron Fouchier in the Netherlands and Yoshihiro Kawaoka in Madison, Wisconsin have begun a “research enterprise” aimed at creating mammalian-airborne-transmissible, highly pathogenic, avian-influenza live viruses. Such viruses could be transmitted through the air, similar to seasonal human influenza.
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Perspective: PandemicsEbola One Year on: The Wins, the Setbacks, and the Way Forward
The last five years have witnessed the two biggest outbreaks of Ebola, first in West Africa and currently in the Democratic Republic of Congo (DRC). The DRC is no stranger to Ebola and has battled the virus on nine previous occasions since 1976. The current outbreak, for a multitude of socio-political reasons, refuses to give in to efforts by an international team of health care workers, armed with vaccines and treatment regimes, which did not even exist during previous episodes. As the outbreak surpasses its one year mark, the virus has infected over 3000 people and claimed more than 2000 lives.
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Medical informationWhat Data Hackers Can Get about You from Hospitals
When hospitals are hacked, the public hears about the number of victims – but not what information the cybercriminals stole. New research uncovers the specific data leaked through hospital breaches, sounding alarm bells for nearly 170 million people.
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PerspectiveAnthrax Redux: Did the Feds Nab the Wrong Guy?
On 18 August 2008—after almost seven years, nearly 10,000 interviews, and millions of dollars spent developing a whole new form of microbial forensics—some of the FBI announced that it had concluded that Army biodefense researcher Bruce Ivins was the person responsible for the fall 2001 anthrax letter attacks. “It’s been 10 years since the deadliest biological terror attack in U.S. history launched a manhunt that ruined one scientist’s reputation and saw a second driven to suicide, yet nagging problems remain,” Noah Shachtman writes. “Problems that add up to an unsettling reality: Despite the FBI’s assurances, it’s not at all certain that the government could have ever convicted Ivins of a crime.”
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The long view
Perspective: Designer pathogensIs There a Role for the Biological Weapons Convention in Oversight of Lab-Created Potential Pandemic Pathogens?
Fourteen labs in the United States are working on creating mammalian-airborne-transmissible, highly-pathogenic, avian-influenza live viruses. These viruses are examples of lab-created potentially pandemic pathogens that bring up questions reflecting real concerns: Should details of this dual-use research be published? Could lab-created potentially pandemic pathogens be accidentally released from a laboratory into the community and seed a human pandemic? Could they be employed as biological weapons? The probability of accidental release into the community from one of the laboratories in this research enterprise is uncomfortably high. For these and other lab-created potentially pandemic pathogens, just one laboratory-infected researcher could seed a pandemic. Furthermore, a laboratory worker with hostile intent could introduce a potentially pandemic pathogen into the community.
Perspective: Preventable diseasesMeasles Epidemic: Parents Reluctant to Vaccinate Their Children Need to Hear of the Horrors of Forgotten Diseases
There’s been a surge in measles cases across Europe, putting people’s lives at risk according to new findings from the World Health Organization. This has in part been put down to disinformation about the MMR (measles, mumps and rubella) vaccine on social media putting parents off vaccinating their children. Why are people reluctant to have screening tests and vaccinations to prevent diseases? Sarah Pitt writes in The Conversation that while some of the reasons may include loss of trust in “experts” and people in authority, I wonder if it is also partly because the stories of such diseases have been long forgotten. “Gruesome photos on cigarette packages, for example, massively help to reduce tobacco use, so maybe something similar now needs to happen in terms of vaccinations to tackle the latest epidemic and anti-vaxxer campaigns around the world,” she writes.
Perspective: ApocalypseIn the Event of a Killer Asteroid, Volcanic Apocalypse, or Nuclear Holocaust, Mushrooms Could Save Humanity from Extinction
About 66 million years ago, an asteroid plummeted through Earth’s atmosphere and crashed into the sea floor, creating an explosion over 6,500 times more powerful than the nuclear bomb the U.S. dropped on Hiroshima. The impact sent clouds of debris and sulfur into Earth’s atmosphere, blocking the sun’s light and warmth for about two years. Photosynthesis ground to a halt, which meant no more plant growth. The surviving dinosaurs starved to extinction. But fossil records show that fungi thrived in the aftermath. “Blot out the sun, and even the best-prepared survivalist, a master of the wilderness, will starve to death along with everyone else,” Bryan Walsh writes in his new book, End Times. In order to survive, he says, people would need to adopt sunlight-free agriculture — cultivating mushrooms, rats, and insects.
Perspective: Mind gamesThe Secret History of Fort Detrick, the CIA’s Base for Mind Control Experiments
Suburban sprawl has engulfed Fort Detrick, an Army base 50 miles from Washington in the Maryland town of Frederick. seventy-six years ago, however, when the Army selected Detrick as the place to develop its super-secret plans to wage germ warfare, the area around the base looked much different. In fact, it was chosen for its isolation. For decades, much of what went on at the base was a closely held secret. Directors of the CIA mind control program MK-ULTRA, which used Detrick as a key base, destroyed most of their records in 1973. Some of its secrets have been revealed in declassified documents, through interviews and as a result of congressional investigations. Together, those sources reveal Detrick’s central role in MK-ULTRA and in the manufacture of poisons intended to kill foreign leaders.
Perspective: PandemicsThe World Knows an Apocalyptic Pandemic Is Coming
A new independent report compiled at the request of the United Nations secretary-general warns that there is a “very real threat” of a pandemic sweeping the planet, killing up to 80 million people. A deadly pathogen, spread airborne around the world, the report says, could wipe out almost 5 percent of the global economy. And we’re not ready. Laura Garrett writes that twenty-five years ago, in 1994, she published her book on the subject, The Coming Plague: Newly Emerging Diseases in a World Out of Balance, arguing that human disruption of the global environment, coupled with behaviors that readily spread microbes between people and from animals to humans, guaranteed a global surge in epidemics, even an enormous pandemic. She writes that epidemic outbreaks were aided and abetted by inept health systems, human behavior, and the complete lack of consistent political and financial support for disease-fighting preparedness everywhere in the world. Will the UN report’s warning be heeded now?
Perspective: Biosafety labsBiosafety Levels in Laboratories – What is the Difference?
The United States is home to several types of laboratories that conduct medical research on a variety of infectious biological agents to promote the development of new diagnostic tests, medical countermeasures, and treatments. The CDC has devised a system of Biosafety Labs (BSL) designations. Ranked from lowest to the highest level of containment, they are BSL-1, BSL-2, BSL-3, and BSL-4. The BSL designations outline specific safety and facility requirements to achieve the appropriate biosafety and biocontainment. The BSL is assigned based on the type of infectious agent on which the research is being conducted. For example, a BSL-4 conducts research on dangerous and exotic agents with a high-risk of causing life-threatening disease, the possibility of aerosol transmission, and no known treatment or therapy (e.g., Marbug virus, Congo-Crimean virus, Ebola virus).