• AnthraxUrban legend: WWI-era “viable” anthrax strain was, in fact, much younger standard laboratory strain

    A team of international researchers has found that a strain of anthrax-causing bacterium thought to have been viable eighty years after a thwarted First World War espionage attack, was, in reality, a much younger standard laboratory strain. The team speculates that the mix-up was due to commonplace laboratory contamination. In 1917, German spy Baron Otto von Rosen was caught in Norway possessing lumps of sugar embedded with glass capillaries filled with a liquid holding spores of Bacillus anthracis, the bacterium that causes anthrax. He was suspected of plotting to feed the sugar lumps, which contained the oldest known isolates of B. anthracis, to the reindeer that pulled transports of munitions and foods across the frozen Arctic tundra for the Allied forces.

  • InfectionsDifferentiating viral and bacterial infections

    MeMed, an Israeli company specializing in molecular immunology, informatics, clinical infectious diseases and in vitro diagnostics, last week announced it has been awarded a $9.2 million contract by DoD’s Defense Threat Reduction Agency (DTRA) to fund the completion of MeMed’s point-of-care platform for distinguishing bacterial from viral infections.

  • AnthraxInternational anthrax conference will explore latest scientific research findings

    Scientists and researchers from all over the world who work on Bacillus anthracis, the causative agent of anthrax, and B. cereus and B. thuringiensis, two closely related bacillus species, will be heading to Victoria, British Columbia, in October for the international conference known as “Bacillus ACT.” The bi-annual conference, set for 1-5 October, will allow members of the scientific community to present their work and meet more than 200 global peers.

  • BioterrorismBioterrorists, using genetic editing, could kill more than 30 million people: Bill Gates

    A bioterrorist attack could kill thirty million people — and such an attack is becoming more likely because it has become much easier to create – or “design” — deadly pathogens and spread them. Bill Gates, Microsoft founder, speaking in London, said that an outbreak of a lethal respiratory virus like smallpox would be more dangerous than even a nuclear attack. Anyone can now purchase chemistry kits which allow genetic editing, and do so online for under $150.

  • Yellow feverPreventing yellow fever resurgence

    Many people might not have heard of the Aedes aegypti mosquito until this past year, when the mosquito, and the disease it can carry – Zika – began to make headlines. But more than 220 years ago, this same breed of mosquito was spreading a different and deadly epidemic in Philadelphia and just like Zika, this epidemic is seeing a modern resurgence, with Brazil at its epicenter. “The challenge with diseases like yellow fever and Zika is that the conditions that foster an outbreak are not always avoidable, especially in tropical climates, and therefore a vaccine is needed to prevent infection,” says one expert.

  • EpidemicsImproving speed, effectiveness of clinical trials during an epidemic

    Mobilization of a rapid and robust clinical research program that explores whether investigational therapeutics and vaccines are safe and effective to combat the next infectious disease epidemic will depend on strengthening capacity in low-income countries for response and research, engaging people living in affected communities, and conducting safety trials before an epidemic hits, says a new report. Using key lessons learned from the Ebola epidemic in West Africa, the report outlines how to improve the speed and effectiveness of clinical trial research while an epidemic is occurring, especially in settings where there is limited health care and research infrastructure.

  • EpidemicsA big-picture look at the world’s worst Ebola epidemic: West Africa, 2013-2016

    The 2013-2016 West African Ebola epidemic dwarfed all previous central African outbreaks of the virus, sickening more than 28,000 people and killing more than 11,000 of them. New study of the epidemic reveals insights into factors that sped or slowed the rampage – for example, that the epidemic unfolded in small, overlapping outbreaks with surprisingly few infected travelers sparking new outbreaks elsewhere, each case representing a missed opportunity to break the transmission chain and end the epidemic sooner. Scientists call for using real-time sequencing and data-sharing to contain future viral disease outbreaks.

  • EpidemicsImproving predictions of outbreaks of Ebola, Lassa fever

    Many of the major new outbreaks of disease, particularly in Africa, are so-called zoonotic infections, diseases that are transmitted to humans from animals. The Ebola virus, for example, which recently killed over 11,000 people across Africa, was most likely transmitted to humans from fruit bats. Potential outbreaks of diseases such as Ebola and Lassa fever may be more accurately predicted thanks to a new mathematical model developed by researchers at the University of Cambridge. This could in turn help inform public health messages to prevent outbreaks spreading more widely.

  • Food security In West Africa, investment key in adapting to climate change

    Climate change will likely have negative impacts on food production in West Africa, with crop yields and grass for livestock grazing likely to decline in the future. A new study provides insights on how strategic planning by decision makers could ease or exacerbate food security challenges in the region.

  • Chemical weaponsMedical evidence confirms sarin gas was used in Syria chemical attack

    Turkey’s health minister said that traces of sarin gas have been detected in blood and urine samples from victims injured in the town of Khan Sheikhun in Syria on 4 April, offering “concrete evidence” of its use in the attack. Isopropyl methylphosphonic acid, a chemical which sarin degrades into, was found in the blood and urine samples taken from the patients who arrived in Turkey. Many of the victims of last week’s attack were taken to Turkey for treatment because the Assad regime and Russia, as part of their war strategy, have destroyed many of the medical facilities in the Sunni areas of Syria.

  • Chemical weaponsEnzymes versus nerve agents: Designing antidotes for chemical weapons

    By Ian Haydon

    Nerve agents, a class of synthetic phosphorous-containing compounds, are among the most toxic substances known. Brief exposure to the most potent variants can lead to death within minutes. Once nerve agents enter the body, they irreversibly inhibit a vitally important enzyme called acetylcholinesterase. Its normal job within the nervous system is to help brain and muscle communicate. When a nerve agent shuts down this enzyme, classes of neurons throughout the central and peripheral nervous systems quickly get overstimulated, leading to profuse sweating, convulsions and an excruciating death by asphyxiation. There is a path to mitigate the danger of chemical weapons. This route lies within the domains of science – the very same science that produced chemical weapons in the first place. Researchers in the United States and around the world are developing the tools needed to quickly and safely destroy nerve agents – both in storage facilities and in the human body. There are promising advances, but no enzyme yet exists which is efficient enough for lifesaving use in people. It is worth keeping in mind the awesome and often complex power of science, however: We may be only a few years away from developing the kind of therapeutics that would make chemical weapons a worry of the past.

  • Infectious diseasesMonitoring the emergence of infectious diseases

    Zoonotic diseases that pass from animal to human are an international public health problem regardless of location — being infected with Campylobacter from eating undercooked chicken in the U.K. is not uncommon, for example — but in lower-income countries the opportunities for such pathogens to enter the food chain are amplified.

  • R&DStudy: NIH funding generates large numbers of private-sector patents

    By Peter Dizikes

    Research grants issued by the National Institutes of Health (NIH) contribute to a significant number of private-sector patents in biomedicine, according to a new study. The study, published in the journal Science, examines twenty-seven years of data and finds that 31 percent of NIH grants, which are publicly funded, produce articles that are later cited by patents in the biomedical sector. “The impact on the private sector is a lot more important in magnitude than what we might have thought before,” says one of the researchers.

  • Zika virusAddressing the threat of Zika virus to the U.S. blood supply

    Investigators have shown that certain screening methods that detect the genetic material of Zika virus can be used to ensure that donated blood supplies remain free of the virus. The methods, called Zika virus nucleic acid amplification technology assays, demonstrated similar excellent sensitivities to assays currently used for screening for transfusion-transmitted viruses. The methods were substantially more sensitive than most other laboratory-developed and diagnostic Zika virus assays.

  • Zika virusPredicting Zika hot spots in the U.S.

    Where in the continental United States is Zika most likely to occur? Researchers puts the bulls-eye of Zika transmission on the Mississippi delta. They also predicted the virus, which is spread sexually and by bites from the Aedes aegypti mosquito, is likely to be transmitted in southern states extending northward along the Atlantic coast and in southern California.