Viruses and pathogens

  • SuperbugsKilling superbugs dead

    The overuse of antibiotics has created strains of bacteria resistant to medication, making the diseases they cause difficult to treat, or even deadly. Now, however, researchers have identified a weakness in at least one superbug that scientists may be able to medically exploit.

  • Public healthDesigner bacteria show way for better vaccines

    Researchers have developed a menu of sixty-one new strains of genetically engineered bacteria that may improve the efficacy of vaccines for diseases such as flu, pertussis, cholera, and HPV. The strains are part of a new class of biological “adjuvants” that is poised to transform vaccine design. Adjuvants are substances added to vaccines to boost the human immune response.

    • University of Florida Clinical Toxicology Online Graduate Course. Chemical Weapons of Mass Destruction. Arm yourself with knowledge.
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  • Public healthNew way to design vaccines: modifying antibodies to trigger immune response

    In an approach with the potential to aid therapeutic vaccine development, scientists have shown that enzymatically modified antibodies can be used to generate highly targeted, potent responses from cells of the immune system

  • PandemicsPigs in southern China found to be infected with avian flu

    Researchers report for the first time the seroprevalence of three strains of avian influenza viruses in pigs in southern China, but not the H5N1 avian influenza virus; their research has implications for efforts to protect the public health from pandemics

  • Food securityRinderpest: how the world’s deadliest cattle plague was eradicated

    Rinderpest, the deadliest of cattle diseases, was declared vanquished in May 2011; after smallpox, it is only the second disease (and first livestock disease) ever to be eradicated from the earth; the insights gained from the eradication campaign may be applied to similar diseases that today ravage the livestock populations on which the livelihoods of one billion of the world’s poor depend; the lessons could also be applied to “zoonotic” diseases which are responsible for 2.4 billion cases of human illness and 2.2 million deaths per year

     

  • MalariaNew synthesis devised for most useful, yet expensive, antimalarial drug

    In 2010 malaria caused an estimated 665,000 deaths, mostly among African children; now, chemists have developed a new synthesis for the world’s most useful antimalarial drug, artemisinin, giving hope that fully synthetic artemisinin may help reduce the cost of the live-saving drug in the future

  • Public healthNear-instantaneous DNA analysis

    Polymerase chain reaction (PCR) is an indispensible technique allowing researchers and clinicians to produce millions of copies from a single piece of DNA or RNA for use in genome sequencing, gene analysis, inheritable disease diagnosis, paternity testing, forensic identification, and the detection of infectious diseases; PCR for point-of-care, emergency-response, or widespread monitoring applications needs to be very fast — on the order of a few minutes; this has now been achieved

  • Public healthAntibiotic residues in sausage meat may promote pathogen survival

    Antibiotic residues in uncured pepperoni or salami meat are potent enough to weaken helpful bacteria that processors add to acidify the sausage to make it safe for consumption; sausage manufacturers commonly inoculate sausage meat with lactic-acid-producing bacteria; by killing the bacteria that produce lactic acid, antibiotic residues can allow pathogenic bacteria to proliferate

  • WaterBacteria in tap water traced to the water treatment process

    Most of the bacteria that remain in drinking water when it gets to the tap can be traced to filters used in the water treatment process, rather than to the aquifers or rivers where they originated; the findings could open the door to more sustainable water treatment processes that use fewer chemicals and, as a result, produce lower levels of byproducts that may pose health risks; eventually, the work could enable engineers to control the types of microbes in drinking water to improve human health

  • Public healthResearchers move a step closer toward universal flu vaccine and therapies

    Researchers describes three human antibodies that provide broad protection against Influenza B virus strains; the same team had previously reported finding broadly neutralizing antibodies against Influenza A strains; the work is a key step toward “universal” vaccine and therapies against flu

  • Public healthDeadly E. coli strain decoded

    The secret to the deadly 2011 E. coli outbreak in Germany has been decoded; the deadliest E. coli outbreak ever, which caused fifty-four deaths and sickened more than 3,800 people, was traced to a particularly virulent strain that researchers had never seen in an outbreak before

  • Public healthDemystifying viruses' copying mechanism allows new vaccines for elusive viruses

    Certain kinds of viruses such as those that cause the common cold, SARS, hepatitis, and encephalitis, copy themselves using a unique mechanism, according to researchers; the discovery sheds light on a previously identified, but never-before-understood region of an enzyme associated with the process of replicating genetic material

  • Food safetyPoultry vaccines found to combine into new viruses

    Researchers found that two different vaccine viruses — used simultaneously to control the same condition in chickens — have combined to produce new infectious viruses, prompting early response from Australia’s veterinary medicines regulator

  • Food securityA world free of foot-and-mouth disease within sight

    The Departments of Homeland Security and Agriculture have developed a novel vaccine for one of the seven strains of the dreaded foot-and-mouth disease (FMD), paving the way for the development of the others; FMD is one of the most economically devastating diseases in the world for those who raise cows, sheep, pigs, goats, deer, and other cloven-hoofed animals is foot-and-mouth disease

  • MalariaImproving malaria control and vaccine development

    Each year more than 250 million people worldwide contract malaria, and up to one million people die; malaria is particularly dangerous for children under five and pregnant women; Plasmodium falciparum is the most lethal of the four Plasmodium species, and is responsible for most clinical disease