• AnthraxAnthrax capsule vaccine completely protects monkeys from lethal inhalational anthrax

    Vaccination with the anthrax capsule — a naturally occurring component of the bacterium that causes the disease — completely protected monkeys from lethal anthrax infection, according to a new study. These results indicate that anthrax capsule is a highly effective vaccine component that should be considered for incorporation in future generation anthrax vaccines.

  • Infectious outbreaksInfectious outbreaks must be combatted strategically: Experts

    New funding is not enough to guarantee success against emerging infectious diseases around the world. Rather, good governance, a long-term technology investment strategy, and strong product management skills are essential. As momentum builds for an international effort to develop drugs and vaccines for emerging infectious diseases, experts examine U.S. biodefense programs to understand approaches that might work and developed a global strategy for countermeasure development.

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  • Public healthStagnant U.S. funding for tools against infectious diseases leaves U.S., world at serious risk

    As Congress grapples with the White House on how to fund an emergency response to fight Zika virus, a new report warns that overall underfunding for development of lifesaving tools against neglected global diseases is putting the United States and the world at risk, and that emergency funding cannot be allowed to substitute for sustained U.S. investment in research and development (R&D) of global health technologies. A recent study that examined the risk of infectious disease outbreaks projected that large-scale global disease pandemics could cost the global economy more than $60 billion a year, while investing in the interventions needed to protect against these outbreaks, including R&D, would cost only a fraction of that — $4.5 billion — each year.

  • Super bugsResistance-proof antiviral can treat many diseases

    Scientists and health officials are marshalling forces to fight Zika, the latest in a string of recent outbreaks. Many of these efforts target that virus specifically, but some researchers are looking for a broader approach. The new strategy aims to fight a wide range of viruses that appears to be safe in vivo and could evade a virus’s ability to develop resistance.

  • Public healthMost vaccine-related posts on Pinterest are anti-vaccine: Study

    About 75 percent of the vaccine-related posts on Pinterest are negative toward vaccination, according to new research. Messages ranged from simple posts questioning the safety of vaccines to more radical claims that vaccines are being created to kill people. Twenty percent of the posts talked about conspiracy theories, such as pharmaceutical companies out to make money at the expense of children and governments trying to harm children for the purposes of population control. The authors are calling for better communication about vaccination.

  • First responseFDA clears military traumatic wound dressing for use in civilian population

    Early control of severe bleeding may prevent shock and may be life-saving., as 30 to 40 percent of civilian deaths by traumatic injury are the result of hemorrhaging. Of those deaths, 33 to 56 percent occur before the patient reaches a hospital. Last week the FDA cleared the use of the XSTAT 30 wound dressing, an expandable, multi-sponge dressing used to control severe, life-threatening bleeding from wounds in areas that a tourniquet cannot be placed (such as the groin or armpit) in battlefield and civilian trauma settings.

  • EbolaStudy finds that Ebola vaccine is safe, stimulating strong immune responses

    A clinical trial of a new Ebola vaccine that resulted from an unprecedented global consortium assembled at the behest of the World Health Organization (WHO) has found that it is well tolerated and stimulates strong immune responses in adults in Mali, West Africa and in the United States. If the vaccine is ultimately found to be safe and effective, it could offer crucial protection for contacts (family members, neighbors, etc.) of patients with confirmed Ebola disease in future epidemics, thereby helping to interrupt transmission. Larger trials of the vaccine sponsored, by GSK Biologicals, have already begun.

  • Public healthOne in 8 children in U.S. at risk for measles

    Gaps in measles vaccination rates in the United States place one in eight children at risk for becoming sick from the highly contagious illness, according to an analysis of national vaccination coverage. Measles can lead to pneumonia, encephalitis, hospitalization and occasionally, death. Those who are not vaccinated or are undervaccinated are highly susceptible to becoming ill because measles is very contagious through direct contact and droplets that can spread through the air.

  • BioterrorismHHS in strategic alliance to accelerate new antibiotic development

    Multiple drugs to combat bioterrorism threats and other life-threatening bacterial infections will be developed under a public-private partnership agreement between the U.S. Department of Health and Human Services’ Office of the Assistant Secretary for Preparedness and Response (APSR) and AstraZeneca, a global biopharmaceutical company. The partnership will also stimulates pipeline of drugs to treat multi-drug resistant bacterial infections. CDC has estimated that in the U.S. antibiotic-resistant bacteria are responsible for two million infections and 23,000 deaths annually with an estimated annual economic burden of $35 billion on the healthcare system.

  • AnthraxPfenex awarded contract valued at up to $143.5 million to develop anthrax vaccine

    San Diego, California-based Pfenex Inc. the other day announced it has signed a five year, cost plus fixed fee contract valued at up to $143.5 million with the Biomedical Advanced Research and Development Authority (BARDA) of the Department of Health and Human Services (HHS), for the advanced development of Px563L, a mutant recombinant protective antigen anthrax vaccine. The company says the U.S. government is looking to have a stockpile of seventy-five million doses.

  • EbolaSingle dose Ebola vaccine is safe and effective in monkeys against outbreak strain

    National Institutes of Health (NIH) scientists report that a single dose of an experimental Ebola virus (EBOV) vaccine — VSV-EBOV — completely protects cynomolgus macaques against the current EBOV outbreak strain, EBOV-Makona, when given at least seven days before exposure, and partially protects them if given three days prior. The scientists also observed that the experimental VSV-EBOV vaccine appears to provide initial protection by triggering innate virus-fighting host responses; these responses partially protected animals challenged with EBOV-Makona within a week after vaccination.

  • Public heathState immunization laws should eliminate non-medical exemptions: Internists

    Support for eliminating existing exemptions, except for medical reasons, from immunization laws was among the policy recommendations adopted last weekend at the summer meeting of the Board of Regents of the American College of Physicians (ACP). “Allowing exemptions based on non-medical reasons poses a risk both to the unvaccinated person and to public health,” said Wayne J. Riley, M.D., president of ACP. “Intentionally unvaccinated individuals can pose a danger to the public, especially to individuals who cannot be vaccinated for medical reasons.”

  • Public healthCalifornia's strict vaccine bill would not allow vaccination waiver

    Last Thursday, the California State Assembly passed SB227, an amendment to the current vaccine bill which would eliminate a waiver for parents to opt out of having their children vaccinated. The proposal passed on a 46-31 vote and is now going back to the Senate this week to confirm the amendments.Under SB277, students who are not vaccinated would have to be homeschooled or participate in off-campus study programs.

  • Public HealthCalifornia vaccine bill on hold as opposing parents threaten to keep their children out of school

    California Senate Bill 277, which would require parents in California to vaccinate their children as a condition for enrollmentin either public or private schools, is facing opposition, after parents and lawmakers expressed their concerns that some children might be denied an education.

  • Public healthScientists: Global pandemic of fake, sub-standard medicines poses dire risk

    Poor quality medicines are a real and urgent threat that could undermine decades of successful efforts to combat HIV/AIDS, malaria, and tuberculosis, according to the editors of a collection of journal articles published yesterday. Scientists report up to 41 percent of specimens failed to meet quality standards in global studies of about 17,000 drug samples. Among the collection is an article describing the discovery of falsified and substandard malaria drugs that caused an estimated 122,350 deaths in African children in 2013. Other studies identified poor quality antibiotics, which may harm health and increase antimicrobial resistance.