• Funding for Research on Gun Injuries to U.S. Children Gets 30 Times Less Funding Per Death Than other causes

    Firearm injuries kill 2,500 American children each year and send another 12,000 to emergency departments. But a new study finds that the nation spends far less on studying what led to those injuries, and what might prevent and treat them, than it spends on other, less-common causes of death in children between the ages of 1 and 18 years.

  • Engineered Viruses Could Fight Drug Resistance

    In the battle against antibiotic resistance, many scientists have been trying to deploy naturally occurring viruses called bacteriophages that can infect and kill bacteria. Bacteriophages kill bacteria through different mechanisms than antibiotics, and they can target specific strains, making them an appealing option for potentially overcoming multidrug resistance. However, quickly finding and optimizing well-defined bacteriophages to use against a bacterial target is challenging. MIT biological engineers showed that they could rapidly program bacteriophages to kill different strains of E. coli by making mutations in a viral protein that binds to host cells. These engineered bacteriophages are also less likely to provoke resistance in bacteria, the researchers found.

  • Why There’s Still No Lyme Vaccine for Humans

    There is no vaccine for Lyme disease, and Valneva, a French biotech company focused on developing vaccines for infectious diseases, hopes to change that. Valneva’s Lyme vaccine isn’t the first designed for people. Twenty years ago, Reeder could have been immunized. From 1999 to 2002, SmithKline Beecham—now GlaxoSmithKline—sold a Lyme vaccine called LYMErix. But the company pulled LYMErix off the market after a public backlash and a spate of lawsuits. If the new vaccine does make it to market, will it fare any better than LYMErix?

  • Climate Change Could Cause Drought in Wheat-Growing Areas

    In a new study, researchers found that unless steps are taken to mitigate climate change, up to 60 percent of current wheat-growing areas worldwide could see simultaneous, severe and prolonged droughts by the end of the century. Wheat is the world’s largest rain-fed crop in terms of harvested area and supplies about 20 percent of all calories consumed by humans.

  • India-Pakistan Nuclear War Could Kill Millions, Lead to Global Starvation

    A nuclear war between India and Pakistan could, over the span of less than a week, kill 50-125 million people—more than the death toll during all six years of World War II, according to new research. The researchers calculated that an India-Pakistan war could inject as much as 80 billion pounds of thick, black smoke into Earth’s atmosphere. That smoke would block sunlight from reaching the ground, driving temperatures around the world down by an average of between 3.5-9 degrees Fahrenheit for several years. Worldwide food shortages would likely come soon after. Today, India and Pakistan each have about 150 nuclear warheads at their disposal, and that number is expected to climb to more than 200 by 2025.

  • FDA: New Food Safety Dashboard to Track FSMA Progress

    In an effort to enhance compliance with the Food Safety and Modernization Act (FSMA), the Food and Drug Administration (FDA) launched a new dashboard that will track and monitor how companies are implementing parts of the law, and how those changes are affecting the food safety system.

  • Containing a Nuclear Accident with Ground-up Minerals

    Researchers at Sandia National Laboratories are developing a promising new way to prevent the spread of radioactive contamination and contain the hot molten mass that develops within a nuclear reactor during a catastrophic accident. A team of scientists discovered and patented a process for injecting sand-like minerals into the core of a nuclear reactor during an accident to contain and slow down the progression of a meltdown.

  • Global Pandemic Threat: “Human Error” Leak of Lab Virus Now a “Substantial Probability”

    Lynn Klotz, Senior Science Fellow at the Centre for Arms Control and Non-Proliferation said: “There is a substantial probability that a pandemic with over one hundred million fatalities could be seeded from an undetected lab-acquired infection.” Laboratories run by Ron Fouchier in the Netherlands and Yoshihiro Kawaoka in Madison, Wisconsin have begun a “research enterprise” aimed at creating mammalian-airborne-transmissible, highly pathogenic, avian-influenza live viruses. Such viruses could be transmitted through the air, similar to seasonal human influenza.

  • Ebola One Year on: The Wins, the Setbacks, and the Way Forward

    The last five years have witnessed the two biggest outbreaks of Ebola, first in West Africa and currently in the Democratic Republic of Congo (DRC). The DRC is no stranger to Ebola and has battled the virus on nine previous occasions since 1976. The current outbreak, for a multitude of socio-political reasons, refuses to give in to efforts by an international team of health care workers, armed with vaccines and treatment regimes, which did not even exist during previous episodes. As the outbreak surpasses its one year mark, the virus has infected over 3000 people and claimed more than 2000 lives.

  • What Data Hackers Can Get about You from Hospitals

    When hospitals are hacked, the public hears about the number of victims – but not what information the cybercriminals stole. New research uncovers the specific data leaked through hospital breaches, sounding alarm bells for nearly 170 million people.

  • Anthrax Redux: Did the Feds Nab the Wrong Guy?

    On 18 August 2008—after almost seven years, nearly 10,000 interviews, and millions of dollars spent developing a whole new form of microbial forensics—some of the FBI announced that it had concluded that Army biodefense researcher Bruce Ivins was the person responsible for the fall 2001 anthrax letter attacks. “It’s been 10 years since the deadliest biological terror attack in U.S. history launched a manhunt that ruined one scientist’s reputation and saw a second driven to suicide, yet nagging problems remain,” Noah Shachtman writes. “Problems that add up to an unsettling reality: Despite the FBI’s assurances, it’s not at all certain that the government could have ever convicted Ivins of a crime.”

  • The World Knows an Apocalyptic Pandemic Is Coming

    A new independent report compiled at the request of the United Nations secretary-general warns that there is a “very real threat” of a pandemic sweeping the planet, killing up to 80 million people. A deadly pathogen, spread airborne around the world, the report says, could wipe out almost 5 percent of the global economy. And we’re not ready. Laura Garrett writes that twenty-five years ago, in 1994, she published her book on the subject, The Coming Plague: Newly Emerging Diseases in a World Out of Balance, arguing that human disruption of the global environment, coupled with behaviors that readily spread microbes between people and from animals to humans, guaranteed a global surge in epidemics, even an enormous pandemic. She writes that epidemic outbreaks were aided and abetted by inept health systems, human behavior, and the complete lack of consistent political and financial support for disease-fighting preparedness everywhere in the world. Will the UN report’s warning be heeded now?

  • Biosafety Levels in Laboratories – What is the Difference?

    The United States is home to several types of laboratories that conduct medical research on a variety of infectious biological agents to promote the development of new diagnostic tests, medical countermeasures, and treatments. The CDC has devised a system of Biosafety Labs (BSL) designations. Ranked from lowest to the highest level of containment, they are BSL-1, BSL-2, BSL-3, and BSL-4. The BSL designations outline specific safety and facility requirements to achieve the appropriate biosafety and biocontainment. The BSL is assigned based on the type of infectious agent on which the research is being conducted. For example, a BSL-4 conducts research on dangerous and exotic agents with a high-risk of causing life-threatening disease, the possibility of aerosol transmission, and no known treatment or therapy (e.g., Marbug virus, Congo-Crimean virus, Ebola virus).

  • Pesticides May Have Caused Cuban “Sonic Weapon” Symptoms

    A strange illness affecting the brains of Canadian and U.S. diplomats in their countries’ embassies in Havana may have been caused by exposure to pesticides, a new study says. From late 2016 to late 2017, some 40 U.S. and Canadian diplomats in Havana suffered brain damage, and exhibited a range of unusual symptoms, including hearing and vision complications, dizziness, fatigue, disorientation, and headaches. The U.S. government claimed that the diplomats had been attacked by some sort of secret sonic weapon, but a new Canadian study says that the cause was likely an exposure to low-dose exposure to neurotoxins, such as those used in commercial pesticides. From late 2016 to late 2017, Cuban health authorities engaged in an intensive fumigation campaign to block the spread of the Zika virus.

  • Declaring Vaccine Hesitancy One of the Ten Biggest Health Threats in 2019 Is Unhelpful

    The rhetoric is well-known: vaccines work, the science is settled, vaccine-hesitant parents are uninformed or misguided victims of the social media platforms where crooks spread fake science. It is taken as a given that vaccines are similarly and uniformly beneficial – aside from rare side effects – and no sane person would question that. But are vaccines similarly and uniformly beneficial? There is no doubt that vaccines can induce immunological “memory” against their target disease. And, at the population level, this reduces the risk of getting the target disease. Vaccine led to the eradication of smallpox, and we are close to eradicating two other serious infections: polio and measles. But we don’t have a lot of evidence about the overall health effects of vaccines. Everybody has been so sure that vaccines only protected against the target infection, nothing else, and so nobody studied the overall health effects. They were simply assumed to be proportionally beneficial. We do not have the evidence for all vaccines to tell vaccine-hesitant parents that it is overall beneficial for their child to receive each one of them. Rather, we have to acknowledge that there are things about vaccines that have not been investigated very well.