• A new class of antibiotics to fight drug resistance

    According to the World Health Organization, antibiotic resistant is one of the biggest threats to global health today and a significant contributor to longer hospital stays, higher medical costs and increased mortality. An international research team has reported the discovery of a new class of antibiotics.

  • Efficient extraction may improve management of nuclear fuel

    After used nuclear fuel is removed from a reactor, it emits heat for decades and remains radioactive for thousands of years. The used fuel is a mixture of major actinides (uranium, plutonium), fission products (mainly assorted metals, including lanthanides) and minor actinides (i.e., americium, curium and neptunium). After the cesium-137 and strontium-90 fission products decay in a few hundred years, the minor actinides and plutonium generate the most heat and radioactivity. Removal of the minor actinides, especially americium, can help nuclear power producers reduce and better manage the waste stream.

  • A synthesized antibiotic is capable of treating superbugs

    A “game changing” new antibiotic which is capable of killing superbugs has been successfully synthesized and used to treat an infection for the first time—and could lead to the first new class of antibiotic drug in thirty years. The breakthrough is another major step forward on the journey to develop a commercially viable drug version based on teixobactin—a natural antibiotic discovered by U.S. scientists in soil samples in 2015 which has been heralded as a “gamechanger” in the battle against antibiotic resistant pathogens such as MRSA and VRE.

  • Too many hospitalized kids receive preventive antibiotics

    A large new international study indicates that nearly a third of hospitalized children are receiving antibiotics to prevent bacterial infections rather than to treat them, and in many cases are receiving broad-spectrum antibiotics or combinations of antibiotics. This high rate of prophylactic prescribing in pediatric patients and frequent use of broad-spectrum agents suggests a clear overuse of antibiotics in this population and underscores the need for pediatric-specific antibiotic stewardship programs.

  • Sandia transport triathlon puts spent nuclear fuel to the test

    Nuclear power supplies almost 20 percent of U.S. electricity and is the leading carbon-neutral power source. However, it produces between 2,200 and 2,600 tons of spent fuel in the United States each year. Fuel rods become brittle and highly radioactive while powering the nuclear reactor, making safe transportation important. Sandia National Laboratories researchers completed an eight-month, 14,500-mile triathlon-like test to gather data on the bumps and jolts spent nuclear fuel experiences during transportation.

  • Pipe-crawling robot to help decommission DOE nuclear facility

    A pair of autonomous robots developed by Carnegie Mellon University’s Robotics Institute will soon be driving through miles of pipes at the U.S. Department of Energy’s former uranium enrichment plant in Piketon, Ohio, to identify uranium deposits on pipe walls. The CMU robot has demonstrated it can measure radiation levels more accurately from inside the pipe than is possible with external techniques.

  • Climate change to fuel more extreme heat waves in western U.S. by 2020

    Human-caused climate change will drive more extreme summer heat waves in the western United States, including in California and the Southwest as early as 2020, new research shows. Understanding the driving forces behind the projected increase in occurrence and severity of heat waves is crucial for public health security and necessary for communities to develop extreme heat mitigation strategies, said the authors.

  • Identifying the key drivers of high U.S. healthcare spending

    The major drivers of high healthcare costs in the U.S. appear to be higher prices for nearly everything—from physician and hospital services to diagnostic tests to pharmaceuticals—and administrative complexity. The study confirmed that the U.S. has substantially higher spending, worse population health outcomes, and worse access to care than other wealthy countries.

  • Nerve agents: what are they and how do they work?

    The first nerve agents were invented by accident in the 1930s when researchers were trying to make cheaper and better alternatives to nicotine as insecticides. In their search, German scientists made two organic compounds containing phosphorus that were very effective at killing insect pests. However, they soon discovered that, even in minuscule amounts, the substances caused distressing symptoms in humans exposed to them. The two substances – too toxic to be used as commercial insecticides in agriculture – became known as tabun and sarin. Since then, other nerve agents have been developed, but much less is known about them, although they are thought to work in broadly the same way. Unlike street drugs, nerve agents cannot be made in your kitchen or garden shed, on account of their toxicity, even in tiny amounts. Synthesis of nerve agents requires a specialist laboratory, with fume cupboards. As more details emerge from the case of former Russian spy Sergei Skripal, we’ll know more about the precise substance used and how it should be tackled. Either way, nerve agents are horrendously lethal and chemical warfare is an obscene use of chemicals.

  • Low-cost arsenic sensor could save lives

    Worldwide, 140 million people drink water containing unsafe levels of arsenic, according to the World Health Organization. Short-term exposure causes skin lesions, skin cancer and damage to the cognitive development of children, while long-term exposure leads to fatal internal cancers. A new low-cost, easy-to-use sensor which can test drinking water for arsenic in just one minute.

  • New framework for guiding controversial research still has worrisome gaps

    In December the Department of Health and Human Services (HHS) release lifted the funding moratorium on Gain of Function (GoF) research, following the controversial projects involving H5N1 in 2011. The “Framework for guiding funding decisions about proposed research involving enhanced potential pandemic pathogens” is similar to the January 2017 “P3C0 Framework,” and it came with the bonus of restoring funding for such research – but there are still considerable concerns with how GoF research is evaluated and if these frameworks have really addressed the gaps.

  • Bioengineers today emphasize the crucial ingredient Dr. Frankenstein forgot – responsibility

    Mary Shelley was 20 when she published “Frankenstein” in 1818. Two hundred years on, the book remains thrilling, challenging and relevant — especially for scientists like me whose research involves tinkering with the stuff of life. Talk of “engineering biology” makes a lot people squeamish, and technology can turn monstrous, but I read Mary Shelley’s “Frankenstein” not as an injunction against bioengineering as such. Rather, the story reveals what can happen when we – scientists and nonscientists alike – run away from the responsibilities that science and technology demand. Victor Frankenstein was certainly careless and perhaps a coward, unable to own up to the responsibility of what he was doing. We now know that science is best conducted with humility, forethought and in the light of day.

  • Number of people killed by animals in the U.S. remains unchanged

    Bites, kicks, and stings from farm animals, bees, wasps, hornets, and dogs continue to represent the most danger to humans, according to a new study. The study shows that animal encounters remain a considerable cause of human harm and death. Researchers analyzed fatalities in the United States from venomous and nonvenomous animals from 2008-2015. They found that while many deaths from animal encounters are potentially avoidable, mortality rates did not decrease from 2008-2015. Each year in the United States alone, over one million emergency room visits and approximately $2 billion in healthcare spending are attributable to problematic animal encounters.

  • Large-scale study on gun-policy effects finds gaps in existing research, with a few exceptions

    The United States has the highest gun ownership rate in the world, with estimates suggesting that Americans own as many as 300 million guns. More than 36,000 people died of gunshot wounds in the U.S. in 2015, and Americans are 25 times more likely to die by gun homicide than residents of other wealthy countries. One of the largest-ever studies of U.S. gun policy finds there is a shortage of evidence about the effects of most gun laws, although researchers from the RAND Corporation found there is some persuasive evidence about the effects of several common gun policies.

  • Making U.S. health sector more resilient to major disasters

    The health sector in the United States would be far better positioned to manage medical care needs during emergencies of any scale by empowering existing healthcare coalitions to connect community resilience efforts with a network of hospitals equipped to handle disasters, according to a new report. The report’s authors found that while the U.S. health sector is reasonably well prepared for relatively small mass injury/illness events that happen frequently (for example, tornadoes, local disease outbreaks), it is less prepared for large-scale disasters (e.g., hurricanes) and complex mass casualty events (for example, bombings) and poorly prepared for catastrophic health events (for example, severe pandemics, large-scale bioterrorism).