1918 pandemic flu virus mystery solved
The Human influenza A virus usually sees higher mortality rates for infants and the elderly, but the pandemic virus caused extensive deaths in people ages 20 to 40, primarily from secondary bacterial infections, especially pneumonia.
The authors suggest that this likely was because many young adults born from about 1880 to 1900 were exposed during childhood to a putative H3N8 virus circulating in the population, which had surface proteins that were very different from those of the H1N1 virus. In contrast, most individuals born earlier or later than 1880-1900 would have had better protection because they were more likely to have been exposed a virus variant more similar to the 1918 virus.
“You can picture the flu virus as a tiny soccer ball studded with lollipops,” Worobey explained. “The candy part of the lollipop is by far the most potent part of the flu virus, against which our immune system can make antibodies. If antibodies cover all the lollipop heads, the virus can’t even infect you.”
For example, a person exposed to a flu strain studded with blue candy lollipops would have antibodies protecting it from future infections with that flu virus. If faced with a different strain containing red candy, however, that same person would get sick because the “anti-blue” antibodies would not recognize the red lollipops, allowing the virus to slip through the body’s immune defenses unscathed.
“We believe that the mismatch between antibodies trained to H3 virus protein and the H1 protein of the 1918 virus may have resulted in the heightened mortality in the age group that happened to be in their late 20s during the pandemic,” Worobey said.
Worobey said the new perspective applies not only to the pandemic of 1918, but might also explain patterns of seasonal flu mortality and the mysterious patterns of mortality when humans are infected by highly pathogenic avian-origin H5N1 and H7N9 viruses, commonly known as the “bird flu.”
H5N1causes higher mortality rates in young people, and H7N9 causes higher mortality in the elderly. In both cases, the researchers found that the more susceptible age groups were exposed initially, as children, to viruses with a mismatched HA, and may suffer severe consequences similar to young adults faced with a mismatched virus in 1918.
The authors suggest that immunization strategies mimicking the often impressive protection provided by initial childhood exposure to influenza virus variants encountered later in life might dramatically reduce mortality due to both seasonal and novel IAV strains.
The release notes that earlier this year, Worobey and his collaborators published a study in the journal Nature providing the most comprehensive analysis to date of the evolutionary relationships of flu virus across different host species over time. The results revealed a rapid, global replacement of the genes in the avian flu virus coinciding closely with a horse flu outbreak in the 1870s that crippled the economy. They also challenged the accepted wisdom of wild birds as the major reservoir harboring the flu virus, from where it jumps to domestic birds and other species, including humans. Instead, the researchers found a very strong indication of spillover from domestic birds to wild birds.
— Read more in Michael Worobey et al., “Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus,” Proceedings of the National Academy of Sciences (8 April 2014) (doi: 10.1073/pnas.1324197111)
