Scientists support research which increases microbes’ virulence, transmissibility, or host range

Signers of the Scientists for Science statement include researchers from universities and other research centers in the United States, the United Kingdom, Germany, the Netherlands, and Australia. Besides Fouchier and Kawaoka, the list includes such names as Christian Drosten of the University of Bonn, Peter Doherty of the University of Melbourne, Peter Palese of the Icahn School of Medicine at Mt. Sinai in New York City, Vincent Racaniello of Columbia University, and Andrew Pekosz of Johns Hopkins University.

More names added
The release notes that since the statement was posted last week, thirteen more individuals have added their names as “supporting scientists.” They include several U.S. government scientists who signed on as private individuals. Among the latest signers are Ian Lipkin of Columbia and David Morens, Jeffery Taubenberger, and John Yewdell of the National Institute of Allergy and Infectious Diseases.

Paul Duprex, Ph.D., associate professor of microbiology at Boston University, said in an interview that the statement grew out of conversations and e-mail exchanges he had with Racaniello of Columbia and Sean Whelan of Harvard University.

He said the trio talked about “the need to be proactive in explaining what we do and deal with the fact that there are a number of people who can make things worse by scare-mongering in the public…. We came to the conclusion that we had two options: either keep our heads down or explain the importance of basic microbiological research and what it has achieved.”

“That is why Scientists for Science was established and we worked on the statement iteratively with input from Yoshi Kawaoka, for example,” Duprex said.

Research already regulated
The statement says that significant resources have been invested in building biosafety level-3 and level-4 labs globally and in limiting risks through regulations, engineering features, and training. “Ensuring that these facilities operate safely and are staffed effectively so that risk is minimized is our most important line of defense, as opposed to limiting the types of experiments that are done,” it adds.

t goes on to say that studies on dangerous pathogens are already extensively regulated, unlike recombinant DNA research at the time of the Asilomar conference in 1975. Studies involving “select agents” are subject to federal regulations, and research plans for other organisms are reviewed by scientists and funding agencies, while safety committees review risk assessments and mitigation plans.

“If there is going to be further discussion about these issues, we must have input from outside experts with the background and skills to conduct actual risk assessments based on specific experiments and existing laboratories,” the statement says.

“Such conversations are best facilitated under the auspices of a neutral party, such as the International Union of Microbiological Societies or the American Society for Microbiology [ASM], or national academies, such as the National Academy of Sciences [NAS], USA. We suggest they should organize a meeting to discuss these issues.”

The statement closes with a pledge that the group will provide scientists and the public with accurate information and will work to promote “open and unbiased discourse.”

Recent events moved group to act
Duprex said he and his partners had been discussing doing something for a long time but started writing the statement about two weeks ago. He acknowledged that the Cambridge Working Group’s statement was a factor in moving them to act, but said it wasn’t the only one.

“That in addition to many other things crystallized why it’s important for scientists to speak up,” he said. However, “This is not about people fighting with each other, it’s about instructive, proactive, reasonable debate.”

He commented further that “Even though much of the focus and criticism is directed at so called ‘gain of function’ studies, as scientists we see this in a much broader perspective. We expect that www.scientistsforscience.org will be a forum for deliberation among SfS members, to discuss how to carry out experiments with dangerous pathogens safely and to share good practice.”

He added that the group plans to provide facts and commentary and engage in open discourse with other scientists and the public. “We are convinced that using rhetoric or posturing to make points is counterproductive and does not serve science well. When necessary we will proactively respond to statements which are either damaging or simply erroneous.”

Duprex said the group plans to approach the ASM and NAS about organizing a meeting to discuss biosecurity.

— Read more in the 28 July Scientists for Science statement; the 15 July CIDRAP News story on the Cambridge Working Group; the 16 July CIDRAP News item on ECDC statement on GOF research